Jaw and jawbone diseases
The effect of sea-surface collagen (hereafter referred to as MK) on MMP regulation and collagen regeneration.
Marine collagen essence
This collagen is primarily type I collagen, which is obtained from the tissues of fish (skin and scales) or other marine organisms. It has several advantages compared to other collagen sources:
1. Better bioavailability. These peptides are smaller and are absorbed better than those from animal or bird collagen.
2. Greater similarity to human collagen. Particularly the amino acid composition of type I collagen from fish is closer to human collagen.
3. More environmentally friendly. It is often produced from by-products of the fish processing industry.
Scientifically.
The effect of MK on MMP regulation:
1. Modulation of MMP activity. Some studies suggest that MK peptides may reduce the activity of MMP-1, MMP-3, and MMP-9. They may also increase the expression of TIMP-1 (a natural inhibitor of MMPs).
2. Anti-inflammatory effect. MK peptides may reduce the level of inflammatory cytokines. Since inflammation is a promoting factor for excessive MMP activity, reducing inflammation may help balance MMP activity.
Effect on collagen regeneration
1. Stimulation of fibroblasts. MK peptides may stimulate fibroblasts (cells that produce collagen). This promotes the synthesis of new collagen in the skin and other tissues.
2. Provision of amino acids. MK contains glycine, proline, and hydroxyproline - amino acids that are critical for collagen formation. These amino acids are the "building blocks" for the body’s own collagen production.
3. Signaling. MK peptides may act as signaling molecules that stimulate the body’s own collagen production.
Clinical importance from the perspective of oral and bone health.
In the context of periodontitis and implants:
1. Health of the periodontal tissues. Consumption of MK may help strengthen the periodontal tissues, promoting collagen regeneration. This may help create a better barrier against bacteria and reduce the activation of MMPs.
2. Influencing bone metabolism. MK peptides may promote the activity of osteoblasts (cells that form bone tissue). Some studies suggest that marine collagen supplements may contribute to an increase in bone mineral density.
3. Wound healing. MK may accelerate the healing of soft tissues after surgical procedures. This can be particularly beneficial after implantation or following treatment for periodontitis.
Practical recommendations
Supplements.
1. Dosage: Most studies have used 2.5-10 g of MK per day. Results are usually noticeable within 4-12 weeks.
2. Choice of form. Hydrolyzed MK is better absorbed than regular collagen sources. Available in powder, capsule, or liquid form.
3. Optimizing interactions. Vitamin C is a cofactor in collagen synthesis - combining it with MK may enhance effectiveness. Anthocyanins (found in blackcurrants, blueberries) may reduce collagen degradation and promote collagen synthesis.
Food selection.
In addition to supplements, the following foods promote collagen production and MMP regulation:
1. Fish collagen soups - a natural source of collagen.
2. Omega-3 fatty acids (fatty fish) - anti-inflammatory effect.
3. Antioxidant-rich foods - protect collagen from oxidative stress.
4. Zinc (oysters, seeds) - important for collagen synthesis.
5. Copper (nuts, legumes) - helps stabilize collagen structure.
