How to reduce high aMMP-8 levels: strategies from LDD to lifestyle changes

Recommendations for Reducing Collagenolysis Levels When aMMP-8 is High

If the vitamin D level is normal but aMMP-8 (activated MMP-8) is still high (over 20 ng/ml), it indicates ongoing collagenolytic activity that can damage both bone and soft tissues.

Chemicals and Products: Doxycycline in antimicrobial subantimicrobial dose (SDD) or Low Dose Doxycycline therapy (LDD).

Inhibits the activity of MMPs, not their production - Dosage: Typically 20 mg twice a day or 40 mg once a day (much lower than the antimicrobial dose). - Efficacy: Clinically proven effect in reducing MMP-8 activity. - Suitable for: Periodontitis when conventional treatment is not sufficiently effective.

Topical MMP inhibitors:

- Chlorhexidine-containing gels and rinses at 0.12%, 0.05(6)%.

- Usage: According to the dentist’s recommendations, usually as a course of 1-2 weeks. Different tactics depending on the severity of the problem. TMP protocol or Treatment (active treatment phase) 2 weeks, Maintenance (maintenance phase) 1-6 months, Prevention (prevention phase) ongoing. Depending on the phase and severity of the disease, different oral care products are also used.

- Advantages: Act directly in the problem area and reduce the number of bacteria causing the issue.

Additionally, important products to use include:

- Lumoral series - Cranberry mouth rinse - Oral pressure washer - Interdental brush - Dental floss - Tongue scraper - Homeopathic remedies.

The frequency of aMMP-8 testing depends on results, TMP protocol phases, the patient’s home oral care level, and healing desire.

Supplements and natural MMP modulators

Omega-3 fatty acids (high in EPA/DHA):

- Dosage: 2-3 g of EPA+DHA per day.

- Mechanism of action: Reduces inflammation, modulates MMP expression.

- Efficacy: Several studies have shown a decrease in aMMP-8 levels after 8-12 weeks. - Additionally, other general health benefits.

Melatonin:

- Dosage: 1-3 mg before bedtime.

- Mechanism of action: Reduces oxidative stress, regulates MMP expression, promotes collagen synthesis.

Curcumin:

- Dosage: 500-1000 mg per day (with piperine to improve absorption).

- Mechanism of action: Inhibits NF-κB signaling pathway, regulating MMP expression.

- Advantages: Strong anti-inflammatory effects, reduces MMP activation.

Resveratrol:

- Dosage: 100-500 mg per day.

- Sources: As a supplement or naturally in red wine, red grapes.

- Mechanism of action: Activates SIRT1, reducing MMP expression.

Green tea extracts (EGCG):

- Dosage: 300-500 mg of EGCG per day or 3-4 cups of green tea.

- Mechanism of action: Reduces MMP expression, inhibits MMP activity.

Coenzyme Q10:

- Dosage: 100-200 mg per day.

- Mechanism of action: Reduces oxidative stress, improves cellular energy production.

Lifestyle changes to lower aMMP-8.

Anti-inflammatory diet:

Recommendations:

- Plenty of colorful fruits and vegetables (at least 5 servings a day).

- Low intake of processed carbohydrates.

- Foods high in fiber.

- Fermented foods (kimchi, sauerkraut, kefir).

Mechanism of action: Reduces systemic inflammation, which in turn regulates MMP activity.

Stress management:

Maintain a daily routine with sufficient sleep time!

- Avoid screens after 7 PM (effects of blue light) and use more natural light (red light - “old” incandescent bulbs, candles, fireplaces, etc.).

- Evening walks outdoors.

Other methods: Regular mindfulness practice implementation, discipline (self-motivation, healthy routines).

- Justification: Chronic stress increases cortisol levels, which can increase MMP activity.

- Efficacy: It has been found that reducing stress lowers levels of inflammatory biomarkers.

Sleep optimization:

Recommendations: 7-8 hours of quality sleep each day, regular sleep schedule. Go to bed earlier and rise earlier. Live with natural light and energy rhythms.

- Mechanism of action: Promotes melatonin production, reduces oxidative stress and inflammation in the body. Improves relationships, enhances vitality, expands mental awareness.

Moderate physical activity:

Recommendations: 30 minutes of moderate activity on most days.

- Mechanism of action: Regulates inflammation, improves immune function, stabilizes MMP activity.

It is important to remember that the optimal approach is complex and depends on individual factors. These strategies should be implemented in collaboration with a doctor or dentist, especially when using medications or powerful supplements.